我尝试使用OkHttp和Picasso（遵循此答案）对从Firebase存储下载的图像进行磁盘缓存。现在，该应用程序会给出异常和崩溃。

这是 build.gradle ：

apply plugin: 'com.android.application'

android {
    compileSdkVersion 25
    buildToolsVersion "25.0.2"
    defaultConfig {
        applicationId "social.com.networking.social.media.app"
        minSdkVersion 16
        targetSdkVersion 25
        versionCode 1
        versionName "1.0"
        testInstrumentationRunner "android.support.test.runner.AndroidJUnitRunner"
    }
    buildTypes {
        release {
            minifyEnabled false
            proguardFiles getDefaultProguardFile('proguard-android.txt'), 'proguard-rules.pro'
            multiDexEnabled true
        }
    }
}

dependencies {
    compile fileTree(dir: 'libs', include: ['*.jar'])
    androidTestCompile('com.android.support.test.espresso:espresso-core:2.2.2', {
        exclude group: 'com.android.support', module: 'support-annotations'
    })
    compile 'com.android.support:appcompat-v7:25.1.0'
    compile 'com.android.support:design:25.1.0'
    compile 'br.com.mauker.materialsearchview:materialsearchview:1.2.0'
    compile 'com.alirezaafkar:toolbar:1.1.1'
    compile 'com.github.mancj:MaterialSearchBar:0.3.5'
    compile 'com.squareup.picasso:picasso:2.5.2'
    compile 'com.nineoldandroids:library:2.4.0'
    compile 'com.daimajia.slider:library:1.1.5@aar'
    compile 'com.google.code.gson:gson:2.6.2'
    compile 'com.google.firebase:firebase-core:10.0.1'
    compile 'com.google.firebase:firebase-ads:10.0.1'
    compile 'com.google.firebase:firebase-messaging:10.0.1'
    compile "com.google.firebase:firebase-auth:10.0.1"
    compile 'com.google.firebase:firebase-storage:10.0.1'
    compile 'com.google.firebase:firebase-crash:10.0.1'
    compile 'com.squareup.okhttp3:okhttp:3.2.0'
    compile 'com.jakewharton.picasso:picasso2-okhttp3-downloader:1.0.2'
    compile 'com.android.support:multidex:1.0.1'

    compile 'org.parceler:parceler-api:1.1.6'
    annotationProcessor 'org.parceler:parceler:1.1.6'


    testCompile 'junit:junit:4.12'
}
apply plugin: 'com.google.gms.google-services'

完整的堆栈跟踪 ：

Process: social.com.networking.social.media.app, PID: 28258
java.lang.NoClassDefFoundError: Failed resolution of: Lcom/squareup/okhttp/OkHttpClient;
at com.squareup.picasso.OkHttpDownloader.defaultOkHttpClient(OkHttpDownloader.java:31)
at com.squareup.picasso.OkHttpDownloader.<init>(OkHttpDownloader.java:76)
at com.squareup.picasso.OkHttpDownloader.<init>(OkHttpDownloader.java:65)
at social.com.networkingsocialmediaapp.Global.onCreate(Global.java:17)
at android.app.Instrumentation.callApplicationOnCreate(Instrumentation.java:1018)
at android.app.ActivityThread.handleBindApplication(ActivityThread.java:4991)
at android.app.ActivityThread.-wrap1(ActivityThread.java)
at android.app.ActivityThread$H.handleMessage(ActivityThread.java:1555)
at android.os.Handler.dispatchMessage(Handler.java:111)
at android.os.Looper.loop(Looper.java:207)
at android.app.ActivityThread.main(ActivityThread.java:5776)
at java.lang.reflect.Method.invoke(Native Method)
at com.android.internal.os.ZygoteInit$MethodAndArgsCaller.run(ZygoteInit.java:789)
at com.android.internal.os.ZygoteInit.main(ZygoteInit.java:679)

Caused by: java.lang.ClassNotFoundException: Didn't find class "com.squareup.okhttp.OkHttpClient" on path: DexPathList[[zip file "/data/app/social.com.networking.social.media.app-2/base.apk"],nativeLibraryDirectories=[/data/app/social.com.networking.social.media.app-2/lib/arm64, /vendor/lib64, /system/lib64]]
at dalvik.system.BaseDexClassLoader.findClass(BaseDexClassLoader.java:56)
at java.lang.ClassLoader.loadClass(ClassLoader.java:511)
at java.lang.ClassLoader.loadClass(ClassLoader.java:469)
at com.squareup.picasso.OkHttpDownloader.defaultOkHttpClient(OkHttpDownloader.java:31)
at com.squareup.picasso.OkHttpDownloader.<init>(OkHttpDownloader.java:76)
at com.squareup.picasso.OkHttpDownloader.<init>(OkHttpDownloader.java:65)
at social.com.networkingsocialmediaapp.Global.onCreate(Global.java:17)
at android.app.Instrumentation.callApplicationOnCreate(Instrumentation.java:1018)
at android.app.ActivityThread.handleBindApplication(ActivityThread.java:4991)
at android.app.ActivityThread.-wrap1(ActivityThread.java)
at android.app.ActivityThread$H.handleMessage(ActivityThread.java:1555)
at android.os.Handler.dispatchMessage(Handler.java:111)
at android.os.Looper.loop(Looper.java:207)
at android.app.ActivityThread.main(ActivityThread.java:5776)
at java.lang.reflect.Method.invoke(Native Method)
at com.android.internal.os.ZygoteInit$MethodAndArgsCaller.run(ZygoteInit.java:789)
at com.android.internal.os.ZygoteInit.main(ZygoteInit.java:679)

Suppressed: java.lang.ClassNotFoundException: com.squareup.okhttp.OkHttpClient
at java.lang.Class.classForName(Native Method)
at java.lang.BootClassLoader.findClass(ClassLoader.java:781)
at java.lang.BootClassLoader.loadClass(ClassLoader.java:841)
at java.lang.ClassLoader.loadClass(ClassLoader.java:504)
... 15 more

Caused by: java.lang.NoClassDefFoundError: Class not found using the boot class loader; no stack trace available

编辑1：
正如Redman所说，我已经启用了MultiDex，但是它仍然给出相同的错误。据此：developer.android.com/studio/build/multidex.html#keep，我需要确定基本APK中哪些类是必需的。如何确定哪些类是必需的？