快捷方式（由@AndreMiras创建）->使用Pycaw，有关Pycaw的用法可在此处找到

详细方法->首先安装python软件包Comtypes

1. 使用 pip install comtypes

要么

1. 从https://pypi.python.org/pypi/comtypes下载，然后解压缩下载文件夹。在解压缩的文件夹中找到setup.py。打开cmd转到 setup.py 的路径，然后运行命令 python setup.py install

现在只需运行code.py文件，您就可以通过更改函数 SetMasterVolumeLevel（ -25
，None）
的第一个参数来调整音量，第一个参数必须在-65到0之间。我希望在Windows 8中尝试过此代码将在Windows 7上运行。

请参阅最后 几 行代码以找到 音量。SetMasterVolumeLevel（-25，None） 并调整PC的音量

代码

from comtypes import *
import comtypes.client
from ctypes import POINTER
from ctypes.wintypes import DWORD, BOOL

MMDeviceApiLib = \
    GUID('{2FDAAFA3-7523-4F66-9957-9D5E7FE698F6}')
IID_IMMDevice = \
    GUID('{D666063F-1587-4E43-81F1-B948E807363F}')
IID_IMMDeviceEnumerator = \
    GUID('{A95664D2-9614-4F35-A746-DE8DB63617E6}')
CLSID_MMDeviceEnumerator = \
    GUID('{BCDE0395-E52F-467C-8E3D-C4579291692E}')
IID_IMMDeviceCollection = \
    GUID('{0BD7A1BE-7A1A-44DB-8397-CC5392387B5E}')
IID_IAudioEndpointVolume = \
    GUID('{5CDF2C82-841E-4546-9722-0CF74078229A}')

class IMMDeviceCollection(IUnknown):
    _iid_ = GUID('{0BD7A1BE-7A1A-44DB-8397-CC5392387B5E}')
    pass

class IAudioEndpointVolume(IUnknown):
    _iid_ = GUID('{5CDF2C82-841E-4546-9722-0CF74078229A}')
    _methods_ = [
        STDMETHOD(HRESULT, 'RegisterControlChangeNotify', []),
        STDMETHOD(HRESULT, 'UnregisterControlChangeNotify', []),
        STDMETHOD(HRESULT, 'GetChannelCount', []),
        COMMETHOD([], HRESULT, 'SetMasterVolumeLevel',
            (['in'], c_float, 'fLevelDB'),
            (['in'], POINTER(GUID), 'pguidEventContext')
        ),
        COMMETHOD([], HRESULT, 'SetMasterVolumeLevelScalar',
            (['in'], c_float, 'fLevelDB'),
            (['in'], POINTER(GUID), 'pguidEventContext')
        ),
        COMMETHOD([], HRESULT, 'GetMasterVolumeLevel',
            (['out','retval'], POINTER(c_float), 'pfLevelDB')
        ),
        COMMETHOD([], HRESULT, 'GetMasterVolumeLevelScalar',
            (['out','retval'], POINTER(c_float), 'pfLevelDB')
        ),
        COMMETHOD([], HRESULT, 'SetChannelVolumeLevel',
            (['in'], DWORD, 'nChannel'),
            (['in'], c_float, 'fLevelDB'),
            (['in'], POINTER(GUID), 'pguidEventContext')
        ),
        COMMETHOD([], HRESULT, 'SetChannelVolumeLevelScalar',
            (['in'], DWORD, 'nChannel'),
            (['in'], c_float, 'fLevelDB'),
            (['in'], POINTER(GUID), 'pguidEventContext')
        ),
        COMMETHOD([], HRESULT, 'GetChannelVolumeLevel',
            (['in'], DWORD, 'nChannel'),
            (['out','retval'], POINTER(c_float), 'pfLevelDB')
        ),
        COMMETHOD([], HRESULT, 'GetChannelVolumeLevelScalar',
            (['in'], DWORD, 'nChannel'),
            (['out','retval'], POINTER(c_float), 'pfLevelDB')
        ),
        COMMETHOD([], HRESULT, 'SetMute',
            (['in'], BOOL, 'bMute'),
            (['in'], POINTER(GUID), 'pguidEventContext')
        ),
        COMMETHOD([], HRESULT, 'GetMute',
            (['out','retval'], POINTER(BOOL), 'pbMute')
        ),
        COMMETHOD([], HRESULT, 'GetVolumeStepInfo',
            (['out','retval'], POINTER(c_float), 'pnStep'),
            (['out','retval'], POINTER(c_float), 'pnStepCount'),
        ),
        COMMETHOD([], HRESULT, 'VolumeStepUp',
            (['in'], POINTER(GUID), 'pguidEventContext')
        ),
        COMMETHOD([], HRESULT, 'VolumeStepDown',
            (['in'], POINTER(GUID), 'pguidEventContext')
        ),
        COMMETHOD([], HRESULT, 'QueryHardwareSupport',
            (['out','retval'], POINTER(DWORD), 'pdwHardwareSupportMask')
        ),
        COMMETHOD([], HRESULT, 'GetVolumeRange',
            (['out','retval'], POINTER(c_float), 'pfMin'),
            (['out','retval'], POINTER(c_float), 'pfMax'),
            (['out','retval'], POINTER(c_float), 'pfIncr')
        ),

    ]

class IMMDevice(IUnknown):
    _iid_ = GUID('{D666063F-1587-4E43-81F1-B948E807363F}')
    _methods_ = [
        COMMETHOD([], HRESULT, 'Activate',
            (['in'], POINTER(GUID), 'iid'),
            (['in'], DWORD, 'dwClsCtx'),
            (['in'], POINTER(DWORD), 'pActivationParans'),
            (['out','retval'], POINTER(POINTER(IAudioEndpointVolume)), 'ppInterface')
        ),
        STDMETHOD(HRESULT, 'OpenPropertyStore', []),
        STDMETHOD(HRESULT, 'GetId', []),
        STDMETHOD(HRESULT, 'GetState', [])
    ]
    pass

class IMMDeviceEnumerator(comtypes.IUnknown):
    _iid_ = GUID('{A95664D2-9614-4F35-A746-DE8DB63617E6}')

    _methods_ = [
        COMMETHOD([], HRESULT, 'EnumAudioEndpoints',
            (['in'], DWORD, 'dataFlow'),
            (['in'], DWORD, 'dwStateMask'),
            (['out','retval'], POINTER(POINTER(IMMDeviceCollection)), 'ppDevices')
        ),
        COMMETHOD([], HRESULT, 'GetDefaultAudioEndpoint',
            (['in'], DWORD, 'dataFlow'),
            (['in'], DWORD, 'role'),
            (['out','retval'], POINTER(POINTER(IMMDevice)), 'ppDevices')
        )
    ]





enumerator = comtypes.CoCreateInstance( 
    CLSID_MMDeviceEnumerator,
    IMMDeviceEnumerator,
    comtypes.CLSCTX_INPROC_SERVER
)

print enumerator
endpoint = enumerator.GetDefaultAudioEndpoint( 0, 1 )
print endpoint
volume = endpoint.Activate( IID_IAudioEndpointVolume, comtypes.CLSCTX_INPROC_SERVER, None )
print volume
print volume.GetMasterVolumeLevel()
print volume.GetVolumeRange()
#volume.SetMasterVolumeLevel(-65, None) uncomment for 0 volume
#volume.SetMasterVolumeLevel(-1, None) uncomment for full volume
volume.SetMasterVolumeLevel(-25, None) #Change the first argument for controlling the volume remember it should be -ve not less than -65